Oncology/Hematology Research Awards Program Landing Page

Pfizer is pleased to announce the 2018 ASPIRE Breast Cancer Research Awards Program

The ASPIRE Breast Cancer Research Awards Program underscores Pfizer’s commitment to supporting investigators in advancing their academic research in the field of breast cancer.

Mission

The mission of the ASPIRE Awards program is to support clinical research in the field of breast cancer through a competitive grants program.

Background

This program is to support continuous medical research to maximize the available therapies by improving medical knowledge and clinical management of the disease.

Request for Proposals

Pfizer invites investigators to apply for the 2018 ASPIRE Breast Cancer Research Awards program through submission of innovative clinical research proposals designed to accomplish the mission of advancing knowledge of select Pfizer compounds in the treatment and disease management of breast cancer.

Scope of Research Areas

Pfizer is interested in supporting clinical studies in breast cancer, focusing in the following areas:
  • In hormone receptor positive (HR+) advanced breast cancer, safety and efficacy profile of palbociclib/hormone therapy given concurrently with radiation in patients with bone disease
  • In HER2- advanced breast cancer, safety and efficacy profile of talazoparib novel combination (except CDK4/6 inhibitors) in patients with HRD/DDR deficiency
  • In HER2- advanced breast cancer, safety and efficacy profile of gedatolisib plus talazoparib combination in appropriate patients
  • In early stage breast cancer setting, translational end point driven study to explore potential effect of gedatolisib on immune system in regard to PD-1, PD-L1, TILs, and other appropriate markers, with or without an immunotherapy agent
In addition, the following would be of interest: incorporation of a correlative/biomarker component into the proposed clinical study using paired biopsy samples, e.g pre- and post- treatment, liquid biopsy, or PK/PD biomarkers to explore potential mechanism of resistance or response, synergistic effect, and etc.

Available Awards

2018 ASPIRE Breast Cancer Research Awards intend to fund 4 to 6 clinical studies within research scope, for a total of approximately 4 million US dollars. It is open to US investigators. Selection of research proposals will be performed by an independent external review panel of experts.