What areas of research meet the criteria for the ASPIRE Gene and anti-TFPI Therapies for Hemophilia Research Awards?

What areas of research meet the criteria for the ASPIRE Gene and anti-TFPI Therapies for Hemophilia Research Awards?

Pfizer will ONLY consider applications which address one of the following areas of focus for this year’s program

Areas of Research Focus:

  • Basic Science of Gene Therapy for Hemophilia
    • Basic science, tropism, transduction efficiency & tolerability of Adeno-associated virus
    • AAV antibody Titer assessment, reduction, tolerance
    • Role of immunosuppression in managing transaminitis
  • Basic Science of TFPI & Anti-TFPI Monoclonal Antibodies
    • Regulation of Coagulation
    • Basic biology of TFPI interactions with Protein C, ATIII, & Protein S
    • Cross talk among regulators (e.g. Protein S being a co-factor for both Protein C and TFPI)
    • Role of different TFPI pools in regulation of coagulation
    • Pharmacology resulting from concomitant treatments (especially antifibrinolytics) added to anti-TFPI
  • Patients with MILD Hemophilia A or B
    • Patients with MILD Hemophilia A or B
    • Arthropathy: presence, development, clinical burden & Joint damage in mild Hemophilia
    • Quality of Life/Work analysis in mild Hemophilia
    • Clinical profile & healthcare utilization in mild Hemophilia
    • Cost of Care, including non-hemophilia related healthcare utilization in mild Hemophilia. top
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