TTR-FAP Award Recipients Page

Congratulations 2016 Global ASPIRE TTR-FAP Award Winners!

Pfizer’s 2016 Global ASPIRE TTR Amyloidosis competitive grants program awarded 9 grants to advance medical knowledge in TTR Amyloidosis. An expert external committee selected the following proposals for their potential to significantly improve our understanding of the epidemiology, basic science and early diagnosis and treatment of TTR amyloidosis.

Pathomechanism of transmission of TTR-related amyloidosis after domino liver transplantation: why can domino recipients develop FAP in a very short time after liver transplantation
PI: Tsuneaki Yoshinaga (Shinshu University School of Medicine, Japan)

Sumoylation in TTR Amyloidosis. Effect of Tafamidis in patients affected with TTR-Amyloidosis
PI: Fernando Martinez-Valle (Vall d'Hebron Research Institute, Spain)

Autonomic dysfunction in Transthyretin Familial Amyloid Polyneuropathy (TTR-FAP): combining physiological and morphological autonomic biomarkers to aid earlier diagnosis and influence treatment
PI: Valeria Iodice (University College London, United Kingdom)

Continuous real-time monitoring of transthyretin dissociation for improved therapeutic interventiong 
PI: Brett VanVeller (Iowa State University, United States)

Deciphering the genetic network associated with age-at-onset variability: increasing awareness of genetic carriers
PI: Carolina Lemos (Instituto de Investigacao e Inovacao em Saude, Portugal)

Screening for familial amyloid polyneuropathy associated with transthyretin in a non-endemic FAP country
PI: Marcelo Chaves (Hospital San Martin, Argentina)

DETOX-TRIAL: Determination of toxic cardiac effects by transthyretin amyloid
PI: Mathias Konstandin (Heidelberg University Hospital, Germany)

Mechanisms of Sex-Specific Differences in the Pathogenesis of Transthyretin Cardiac Amyloidosis
PI: Kevin Alexander (Brigham and Women's Hospital, United States)


Congratulations 2015 Global ASPIRE TTR-FAP Award Winners!

Pfizer’s 2015 Global ASPIRE TTR-FAP competitive grants program awarded six grants to advance medical knowledge in TTR-FAP. An expert external committee selected the following proposals for their potential to significantly advance our understanding of the epidemiology and important diagnostic issues relevant to treating patients with TTR-FAP.

Proteomic analysis of transthyretin (TTR) post- translational modifications (PTMs) as a disease activity marker in hereditary TTR- related amyloidosis (ATTR) under current treatment options: a proof of concept study
PI: Jose Maria Campistol Plana (Spain)

Early diagnosis and high sensitive methods for evaluating early pathological changes in transthyretin-related familial amyloid polyneuropathy
PI: Mitsuharu Ueda (Japan)

CATCH ATTR__ CArpal Tunnel ligament amyloid: The Clue for early identification of Hereditary or wild-type systemic ATTR amyloidosis
PI: Fabian aus dem Siepen (Germany)

Prevalence of Transthyretin-type Cerebral Amyloid Angiopathy in ATTR-FAP Patients and Its Early Diagnosis Using PiB-PET Imaging 
PI: Yoshiki Sekijima (Japan)

Familial Amyloidotic Polyneuropathy Type I (ATTRV30M) in Cyprus: An updated epidemiological, clinical and genetic study
PI: Theodoros Kyriakides (Greece)

Screening of TTR Mutations in a Sample of Patients with Axonal Polyneuropathy by Melting Curve Analysis
PI: Adriano Jimenez-Escrig (Spain)


2014 Global ASPIRE TTR-FAP Award Winners

Pfizer’s 2014 Global ASPIRE TTR-FAP competitive grants program has awarded four grants to advance the diagnosis of TTR-FAP through early patient identification using novel approaches. An expert external committee selected the following proposals for their potential to significantly advance our understanding of important diagnostic issues relevant to treating patients with TTR-FAP.

A Biomarker Consortium in Familial Amyloid Polyneuropathy
PI: Roy Freeman (USA); Co-Is: Drs. Alejandra Gonzalez-Duarte (Mexico) & Fabio Barosso (Argentina)

Transthyretin gene sequencing and clinical characterization of patients with neuropathies of unknown etiology
PI: Teresa Coelho (Portugal)

Cutaneous nerve measures in TTR-FAP
PI: Michael Polydefkis (USA)

Biomarkers of small fiber neuropathy in amyloid neuropathy
PI: Sung-Tsang Hsieh (Taiwan)